What Is The Difference Between Viagra and Revatio

What Is The Difference Between Viagra and Revatio?

Pfizer’s discovery of Sildenafil Citrate in 1996 was closely followed by the acquisition of a patent for this active pharmaceutical ingredient. Then came the launch of Viagra – the first oral treatment for Erectile Dysfunction and Impotence – and Revatio for Pulmonary Arterial Hypertension two years after. The drugs were explicitly designed for two different therapeutic purposes but the fact they both contained the same active pharmaceutical ingredient had people wondering if there is any difference.

The fact that they both contain Sildenafil Citrate means that the two medications are phosphodiesterase-5 inhibitors. What is the difference between the way the active ingredient works in Erectile Dysfunction treatment and Pulmonary Arterial Hypertension treatment? The former is characterized by the inability of the penis to develop full erections or inability to sustain such erections for long while the latter is characterized by increased blood pressure inside the lungs arteries. Why is Sildenafil good for both?

Revatio 20 mg Vs Viagra

Revatio is a prescription-only medication for Pulmonary Arterial Hypertension that is available in white round tablets in film coating. The only available dosage strength is 20 milligrams. Each 20 milligrams white, round, film-coated tablet contains 20 milligrams Sildenafil Citrate as the main active ingredient. This medication is also formulated in the form of vial bottles containing 10 milligrams Sildenafil in every 12.5ml. Revatio vials are sterile single-use vials and so should be disposed of after a single use.

Viagra Pills

Viagra Pills

Viagra is also a prescription-only medication for male Impotence and Erectile Dysfunction. This medication is available in the blue diamond shaped tablets coated in film. It is produced in three dosage strengths: 25 milligrams, 50 milligrams, and 100 milligrams tablets. Each of the tablets contains a corresponding amount of Sildenafil, which is the main active ingredient. It is sold in packs of eight tablets or otherwise dispensed in prescription bottles containing any amount.

Revatio is not a cure for Pulmonary Arterial Hypertension. The United States Food And Drug Administration approved the medication in 2005 to slow the clinical worsening of this condition and improve the ability to exercise. Sildenafil is present to inhibit phosphodiesterase-5 – an enzyme found on the walls of both the lungs and the surrounding arteries. PDE5 normally degrades the small molecule known as cyclic guanosine monophosphate. With Sildenafil assistance, cGMP levels increase leading to vasodilation (which in turn increases circulation) and a reduction in blood pressure.

Viagra, likewise, is not a cure for Erectile Dysfunction and Impotence. All it does is manage the situation for the period it is active. Phosphodiesterase-5 is also present in the corpus cavernosum in the penis as well as the walls of the surrounding blood vessels. As in PAH, Sildenafil citrate is capable of inhibiting this enzyme and thus, it prevents further breakdown of cGMP in the region. This has the effect of increasing the concentration of cGMP, which is needed to relax the smooth muscles and dilated the blood vessels so they can supply more blood. Erections are stronger as a result.

They both have the same adverse effects including the following, which are very rarely seen if taken as recommended: Hypertension, Tachycardia, Hypotension, Priapism, Arthritis, Stevens Johnson’s Syndrome, Contact Dermatitis, Exfoliative Dermatitis, Dyspnea, Epistaxis, Erythema, Myalgia, Paresthesia, Insomnia, Facial and Limb Edema, sudden Hearing Loss, and Reduced Visual Acuity. Both medications should not be administered concomitantly with nitrates or nitric oxide donors, alpha-blockers, and other PDE5 inhibitors.

Can My Doctor Prescribe Revatio For ED?

The main reason many Erectile Dysfunction patients are interested in finding out if their doctors can prescribe Revatio for the condition is that the drug contains the same active ingredient and it is comparatively cheaper since it is available generically. It seems logical that doctors should not hesitate to prescribe Revatio for ED but you have to remember that since it is only indicated for PAH, such a prescription will be an off-label prescription (a prescription for an unapproved indication).

From the doctors’ point of view, it makes no sense to make an off-label prescription if the same ingredient is obtainable in Viagra film-coated tablets. So, if you are looking for a way to avoid the huge cost of Viagra, you are going to have to look elsewhere. The average cost of thirty pills of one hundred milligrams Viagra is around 745 US dollars or 24.83 US dollars per pill. If you live in the United States, you will have to look for approved generic versions of the medication outside the US. There are a number of those on the shelves of online pharmacy vendors on our TOP list of recommended online pharmacies.

On these Internet drugstores, you will get cost-efficient generic Sildenafil for prices as low as $1 depending on the amount you are purchasing at a time. You also will not be required to present a prior prescription from your doctor although you may have to fill an online questionnaire. It is advisable however that you see a doctor before deciding on a particular generic medication.

Conclusion

Revatio and Viagra both contain Sildenafil Citrate and, as such, are equally capable of inhibiting phosphodiesterase-5 – an enzyme, which is found in the walls of the lungs and surrounding arteries as well as in the corpus cavernosum and surrounding arteries. After PDE5 is inhibited, cGMP levels increase leading to vasodilation (which in turn increases circulation and oxygen transport) and a reduction in blood pressure, in the case of PAH. In ED this has the effect of increasing the concentration of cGMP, which is needed to relax the smooth muscles and dilated the blood vessels, so they can supply more blood. Erections are stronger as a result.

Doctors will not prescribe Revatio for Erectile Dysfunction treatment because it will be an off-label prescription and, more pertinently, the medication has exactly the same active ingredient as Viagra, which is widely available. If you’re looking to cut the cost of Viagra, you may want to consider generic Sildenafil available on pharmacy vendor websites in our TOP list of recommended pharmacies.